Mickael Naassila
University of Picardie, USA
Title: Light Alcohol Intake During Adolescence Induces Alcohol Addiction In Model Of Schizophrenia
Biography
Biography: Mickael Naassila
Abstract
Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting high rate of comorbid use of drugs of abuse. While more than 80%of schizophrenics are smokers, the second drug the most consumed is alcohol with dramatic consequences on frequency and intensity of psychotic episodes and on life expectancy. Here we investigated the impact of light alcohol intake during adolescence on the subsequent occurrence of alcohol addiction like behavior in neonatal ventral hippocampal lesion (NVHL) rats, a neurodevelopmental model of schizophrenia. Our findings demonstrated an increased liability to addictive behaviors in adult neonatal ventral hippocampal lesioned (NVHL) rats after voluntary alcohol intake during adolescence.