Gafarov Valery
FSBI Institute of Internal and Preventive Medicine, Russia
Title: Gender differences in risk of MI and stroke in population with high levels of personal anxiety
Biography
Biography: Gafarov Valery
Abstract
Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting high rate of comorbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second drug the most consumed is alcohol with dramatic consequences on frequency and intensity of psychotic episodes and on life expectancy. Here we investigated the impact of light alcohol intake during adolescence on the subsequent occurrence of alcohol addiction-like behavior in neonatal ventral hippocampal lesion (NVHL) rats, a neurodevelopmental model of schizophrenia. Our findings demonstrated an increased liability to addictive behaviors in adult neonatal ventral hippocampal lesioned (NVHL) rats after voluntary alcohol intake during adolescence. NVHL rats displayed several signs of alcohol use disorder such as a loss of control over alcohol intake and high motivation to consume alcohol, associated with a higher resistance to extinction.